14-3-3 proteins recognize protein partners phosphorylated at serine or threonine in certain sequence motifs in all eukaryotic organisms. The seven human 14-3-3 "isoforms", individually named beta, gamma, epsilon, zeta, eta, sigma, and tau are distinct gene encoded paralogs which are highly similar in sequence and in their phosphopeptide-recognition mode, yet display different expression patterns across tissues. 14-3-3 proteins are highly abundant in most human tissues, where several 14-3-3 isoforms are systematically found among the top 1% of the ~20,000 human gene-encoded proteins. 14-3-3 proteins function as dimers able to bind phosphopeptides. In our database, affinity values are shown of 14-3-3 homodimers.