ProfAff

You are looking at the quantitative interactomic profile of the molecule of SRRM1

UniProt ID: Q8IYB3
Molecule ID: SRRM1 (Link to all interactions of this molecule.)
Alternative name(s): SRRM1 SRM160

The selection have 1 unique variants
non-modified profile

The selection have 14 unique fragments

full-length protein (1-904)
327-341 fragment
365-379 fragment
395-409 fragment
544-558 fragment
557-571 fragment
567-581 fragment
576-590 fragment
600-614 fragment
611-625 fragment
612-626 fragment
621-635 fragment
759-773 fragment
776-790 fragment

The selection have 13 unique sites

PxxP_1 sites
PxxP_10 sites
PxxP_11 sites
PxxP_12 sites
PxxP_13 sites
PxxP_2 sites
PxxP_3 sites
PxxP_4 sites
PxxP_5 sites
PxxP_6 sites
PxxP_7 sites
PxxP_8 sites
PxxP_9 sites

You see an affinity binding profile calculated for macromolecular interactions, where affinities measured using different fragments of the same proteins are combined. To only show affinities of a specific fragment or functional site, select one on the top of the page.

Be careful with the reported affinities and standard deviations because they may be based on an array of measurements performed with unrelated fragments. Always inspect the origin of the measured affinity values by clicking on the reported pKd value in the table.

Partners			Experiment
ID	UniProt	Modification	pK_d Any affinities measured between the same molecules, unless modification-dependent, are averaged on this page.	St.dev Standard deviation is calculated using affinities obtained from independent experiment series. * indicates that affinity was not detectable in all experiments	n	QI Quality indicator n > 1 and St.dev < 0.5 pKd n > 1 and St.dev > 0.5 pKd or only detectable in a subset of experiment series n > 1, but originating from a single experiment series n = 1
BIN1	O00499	V583I	5.26	0.46*	37, detectable in 33
BIN1	O00499	R581C	5.24	0.49*	37, detectable in 33
BIN1	O00499		5.19	0.54*	79, detectable in 73
BIN1	O00499	P551L	5.15	0.44*	37, detectable in 33
BIN1	O00499	T532M	5.13	0.42*	73, detectable in 65
BIN1	O00499	V566M	5.02	0.34*	37, detectable in 33
BIN1	O00499	Q540H	5.00	0.45*	37, detectable in 35
SNX27	Q96L92		4.86	*	21, detectable in 6
AMPH	P49418		4.83	0.51*	40, detectable in 33
BIN1	O00499	D537V	4.64	0.51*	37, detectable in 31
BIN1	O00499	Y531S	4.46	0.60*	37, detectable in 33
ARHGEF7	Q14155		4.35	0.37*	40, detectable in 35
BIN1	O00499	F584S	4.09	0.22*	37, detectable in 10
PRMT2	P55345		4.06	0.18*	40, detectable in 20
ABL1	P00519		4.01	0.24*	40, detectable in 22
OBSCN	Q5VST9		not detectable		40
DLG1	Q12959		not detectable		6
SCRIB	Q14160		not detectable		6
TX1BP3	O14907		not detectable		3

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